Jaw-Shen Tsai was born in 1952 in Taipei. He graduated from the department of physics of University of California at Berkeley in 1975 and subsequently received his Ph.D. in Physics from State University of New York at Stony Brook. His research life has been devoted to the study of macroscopic quantum effect in superconductors, especially which is associated with Josephson junctions. He has contributed to the area of condensed matter physics in both fundamental physics and their technological potential. He led the Josephson-junction-based qubit project at NEC Tsukuba laboratory for many years. He is also the Team Leader of Macroscopic Quantum Simulation Team in RIKEN Center for Quantum Computing. Since 2015, he is a professor of physics at Tokyo University of Science. He has been working on experiments connected to quantum coherence in the Josephson systems. In this direction, his group has been pioneering the science and technology of superconducting quantum computing by demonstrating the first solid-state based qubit (1999), the first solid state CNOT gate (2003), a universal quantum gate operation (2007). Moreover, many important results relating to the quantum optics with artificial superconducting atom were demonstrated. He received Nishina Memorial Prize in 2004, Simon Memorial Prize in 2008, Leo Esaki Prize in 2014, Medal with Purple Ribbon in 2018, Asahi Prize in 2021, and Japan Academy Prize in 2023. He is a fellow of the American Physical Society and a fellow of the Japan Society of Applied Physics.